At approximately 1500 Central time, the airplane was substantially damaged when it collided with trees while on approach. The Private pilot and passenger were seriously injured. Visual conditions prevailed. The pilot subsequently reported, while on final approach, the airplane entered an uncommanded nose-down pitch attitude and banked to the left. Shortly thereafter, the airplane impacted trees and came to rest. Observed weather at a facility 30 miles north of the accident site included wind from 120 degrees at nine knots, gusting to 14.