At 1011 Eastern time, the airplane was substantially damaged during impact with terrain while on approach. The Private pilot was fatally injured; instrument conditions prevailed. The pilot was flying the RNAV (GPS) Runway 35 approach. The tower controller stated he observed the airplane descend from a cloud layer and asked the pilot if she had the runway in sight. The pilot replied affirmative, and the tower controller provided the current wind information. The pilot began to read back the current wind information, when the nose of the airplane pitched up, then down, followed by a rapid descent into terrain.