At about 0950 eastern time, a Piper PA-32-300 lost engine power while cruising at 4,500 feet and crashed near Hamilton. The pilot was killed and the passenger was seriously injured. The VFR flight was under flight following when the pilot reported first a rough running engine and then a complete engine failure. The pilot of a nearby airplane was vectored to the accident site and located the wreckage, then provided directions to lead rescuers to the accident site.